منابع مشابه
Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes.
OBJECTIVE The present studies were performed to examine the degradation of connexin43-containing gap junctions by the lysosome or the proteasome in normal and heat-stressed cultures of neonatal rat ventricular myocytes. METHODS Primary cultures were prepared from neonatal rat ventricular myocytes. Connexin43 was detected by immunoblotting, immunofluorescence, or immunoprecipitation. Gap junct...
متن کاملMathematical modeling of the heat-shock response in HeLa cells.
The heat-shock response is a key factor in diverse stress scenarios, ranging from hyperthermia to protein folding diseases. However, the complex dynamics of this physiological response have eluded mathematical modeling efforts. Although several computational models have attempted to characterize the heat-shock response, they were unable to model its dynamics across diverse experimental datasets...
متن کاملUmbilical Cord Blood-Derived Stem Cells Improve Heat Tolerance and Hypothalamic Damage in Heat Stressed Mice
Heatstroke is characterized by excessive hyperthermia associated with systemic inflammatory responses, which leads to multiple organ failure, in which brain disorders predominate. This definition can be almost fulfilled by a mouse model of heatstroke used in the present study. Unanesthetized mice were exposed to whole body heating (41.2°C for 1 hour) and then returned to room temperature (26°C)...
متن کاملCutaneous Evaporation in Heat-stressed Spotted Sandgrouse’
Many species of desert birds are relatively small (< 500 g), diurnally active ground dwellers that are naturally exposed to high ambient temperatures (T,) and low relative humidities (RH). Sandgrouse (Pteroclididae), being small birds (weighing between 200 and 400 g) having a relatively high standard metabolic rate (SMR), would have to possess an effective mechanism for dissipating heat. Spotte...
متن کاملEvaluation of Hsp47 expression in heat-stressed rat myocardial cells in vitro and in vivo.
The aim of the present study was to identify the correlation between expression of heat shock protein 47 (Hsp47) and stress injury in heat-stressed myocardial cells and to compare variations in Hsp47 expression in rat myocardial cells exposed to different heat stress for varying periods in vitro and in vivo. Exposure to heat stress at 42°C resulted in similar induction patterns of the heart dam...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)63889-x